New PDF release: A Guide to Bone Marrow Transplantation

By H. Joachim Deeg M.D., Hans-Georg Klingemann M.D., Gordon L. Phillips M.D. (auth.)

ISBN-10: 0387548319

ISBN-13: 9780387548319

ISBN-10: 3540548319

ISBN-13: 9783540548317

ISBN-10: 3642973744

ISBN-13: 9783642973741

ISBN-10: 3642973760

ISBN-13: 9783642973765

In 1988 we awarded our consultant to Bone Marrow Transplan­ tation. The reception has been enthusiastic and we now have re­ ceived a flood of severe reviews, feedback and requests to supply an replace in due time. even though numerous books on marrow transplantation have lately been released, their scope and objective have as a rule been varied. accordingly, we now have made up our minds to organize a moment version of the consultant. Our target was once to take care of a quick, concise textual content which by no means­ theless could include alterations that experience happened during the last 4 or 5 years. we have now streamlined the outline of pretransplant issues, through condensing sections into one (Treatment making plans and Timing of Transplantation). This additionally facilitated the evaluate of debatable symptoms for marrow transplantation, for instance in sufferers with acute myelogenous leukemia in first chemotherapy-induced remission. we now have up to date the bankruptcy facing conditioning regimens and feature accelerated the part on donor choice, particularly in regard to the present point of tissue typing and the identity of unrelated volunteer donors. within the bankruptcy on assortment, processing, and infusion of marrow, we now have integrated fresh advancements, for instance, using closed platforms for marrow harvesting and processing and using good part separation of stem cells.

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Be determined, and occasionally it may not be possible to separate phenotypic from genotypic identity. Hence, whenever available, parents should be included in HLA typing studies. Occasionally typing of children may also be useful. Recent development of molecular techniques and their application to HLA typing have refined our ability to characterize differences between patient and donor. , the determination of restriction fragment length polymorphism (RFLP), or hybridization of patient and donor DNA with oligonucleotides of known sequence capable of annealing with the complementary sequences at previously identified highly polymorphic DNA Donor Selection 37 regions (sequence specific oligonucleotide probes, or SSOP), can identify even single base-pair difference.

However, once gene transfer procedures become practical, autologous marrow transplantation may be applicable to certain inherited immunohematologic disorders (Table 3). When using autologous marrow, we are not truly dealing with a transplant procedure since no transfer to a different person is involved, but rather the re-infusion of previously aspirated marrow which one might term autoplantation. The primary advantages of autologous marrow are that it is extensively available and that it lacks the immunologic complications of allogeneic marrow transplants - rejection and GVHD.

Blood 78:1923 Cheson BD, Lacerna L, Leyland-Jones B, Sarosy G, Wittes RE (1989) Autologous bone marrow transplantation. Current status and future directions. Ann Intern Med 110:51-65 Deeg HJ, Self S, Storb R, et al. (1986) Decreased incidence of marrow graft rejection in patients with severe aplastic anemia: Changing impact of risk factors. Blood 68:1363 Fischer A, Durnady A, de Villartay J-P, Vilmer E, Le Deist F, Gerota I, Griscelli C (1986) HLA-Haploidentical bone marrow transplantation for severe combined immunodeficiency using E Rosette fractionation and cyclosporine.

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A Guide to Bone Marrow Transplantation by H. Joachim Deeg M.D., Hans-Georg Klingemann M.D., Gordon L. Phillips M.D. (auth.)


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